Minggu, 29 November 2015

Free PDF The Story of the Human Body: Evolution, Health, and Disease

Free PDF The Story of the Human Body: Evolution, Health, and Disease

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The Story of the Human Body: Evolution, Health, and Disease

The Story of the Human Body: Evolution, Health, and Disease


The Story of the Human Body: Evolution, Health, and Disease


Free PDF The Story of the Human Body: Evolution, Health, and Disease

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The Story of the Human Body: Evolution, Health, and Disease

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Audible Audiobook

Listening Length: 14 hours and 54 minutes

Program Type: Audiobook

Version: Unabridged

Publisher: Random House Audio

Audible.com Release Date: October 1, 2013

Whispersync for Voice: Ready

Language: English, English

ASIN: B00EZ4CTGK

Amazon Best Sellers Rank:

I got a lot out of this book in terms of better understanding the reasons I've had so much trouble controlling my weight over my adult lifetime. In the last few years I've read over a dozen books citing modern research on the dangers of sugar, fat & salt. By understanding how these addictions (especially sugar in my case) affect my body, it's been possible for me - finally - to get myself following a healthy path. This book is a terrific addition to that course of self-study.This book delves into the evolutionary component of why we are like we are today. Truly understanding that goes a long way to helping me make better decisions on the kinds of foods I want to eat, how much and what kind of physical activity really helps me be healthy, and the importance of also getting enough good sleep. Much more than that is covered on what the modern human body has adapted to over the last 600 generations -- and more importantly, how much we've changed due to cultural evolution since man invented farming and the agricultural revolution changed everything. The lifestyle choices we have today were unknown tens of thousands of years ago and our bodies are paying the price for many of our choices… obesity, diabetes, heart disease & cancer to name just a few. All of these were virtually unknown to our long ago ancestors. How we've changed the world we live in, in terms of modern food choices, conveniences and lifestyles is at the root of why these diseases are currently at epidemic levels.So much of what I was taught as a young person was simply… wrong. I just wish I would have started educating myself on this stuff decades ago. I'm now in my 60's and the books I've read over the last couple of years are helping me feel better on a daily basis and have improved my health overall. I'm on no meds, finally at a normal weight, and expect to be active and healthy for another couple of decades. (I couldn't say that 5 years ago.)For further reading on how to help yourself feel better and become healthier start with any of the book by David Gillespie (such as Sweet Poison) or a movie on DVD called That Sugar Film - all available on Amazon.

The story that this book tells is of a human body adapted and optimized for hunting and gathering that has been thrust by agricultural and industrial revolutions into conditions for which it is ill-suited. The central idea is that of the “mismatch disease.” The mismatch in question is a mismatch between the lives humans were evolved to lead and the ones that we have developed through cultural and technological progress. The human body is governed by what Nassim Nicholas Taleb calls “anti-fragility” or what biologists call “phenotypic plasticity.” Both terms say that our bodies get stronger when exposed to physical stressors and weaker in the absence of such stressors. We’ve now used culture and technology to reduce exposure to such stressors, while—at the same time—food is more available than ever and is in calorically dense / nutritionally sparse forms. This mismatch accounts for many problems. Of course, technology has also allowed us to reduce our exposure to dirt and germs, and this, after being once a boon, has begun to swing us into dangerous territory.The 13 chapters (including the introduction) are divided into three parts in a logical manner to address the book’s objective. After an introduction that lays groundwork for understanding human evolution in a broad sense, the first part describes human evolution up to the point where culture became dominant force for our species. It clarifies how we became bipedal, how our diets developed, how we got smart, and the ways in which the aforementioned characteristics are interconnected. The second part shifts from Darwinian evolution to cultural evolution, and—in particular—elucidates the effects that the agricultural and industrial revolutions had on the human body. These cultural forces act much faster than evolution. While some argue that humans aren’t really subject to evolutionary forces anymore, owing to cultural and technological advances, Lieberman points out that Darwinian evolution does still effect humanity, but its effect is muted by comparison to fast-acting cultural developments. The final part looks at humanity in the present and projects out into the future. It considers what effect an over-abundance of energy and a declining need for physical activity have had on our species, and what can be done about it.This book is thought-provoking, well-organized, and uses narrative evidence and humor to enhance readability. (A discussion of the absurdity of products in the Skymall catalog—e.g. luxury items for pet—is a case in point.) It certainly gives on a good education about human evolution. Furthermore, while there are many books out there that deal with mismatch as a cause of diseases like obesity and diabetes, Lieberman also addresses under-explored issues like postural problems from chairs, the influence of shoes on running gait, and the development of nearsightedness because of our close-focusing ways.I’d say the book’s greatest flaw comes in its discussions of solutions at the end. The author puts all his eggs in the basket of wholesale solutions aimed to make society as a whole improve, while he could do more to share the details of what individuals can do to solve their own problems. Lieberman considers why natural selection won’t solve problems of mismatch and dysevolution. Then he considers how research and development and educational campaigns can only provide partial solutions. His ultimate solution is suggesting regulatory paternalism—e.g. what economists call Pigovian taxes--taxes designed to change behavior by making bad behavior (in this case sedentary lifestyles and over-eating / malnutrition) more expensive. Perhaps such solutions (which will remain political untenable for the foreseeable future in the US, at least) may be necessary, but one shouldn’t conclude that readers with better information and ways of approaching the problem can’t make a difference. I say this based upon the fact that a substantial (if minority) portion of the population is already doing the right thing—eating right, exercising, and not succumbing to modernity’s creature comforts. I, furthermore, say it as a one trained as an economist who has seen easier attempts at paternalism fail over and over again.I’d recommend this book. I think it gives the reader insight into the problems caused by being evolved to be one thing while being groomed by culture to be another.

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Rabu, 11 November 2015

Download PDF Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt

Download PDF Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt

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Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt

Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt


Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt


Download PDF Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt

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Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt

Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials provides a concise presentation of the principles applied in this area. It details the concepts behind randomization and methods for designing and analyzing trials and also includes information on meta-analysis and specialized designs, such as cross-over trials, cluster-randomized designs, and equivalence studies.

This latest edition features new and revised references, examples, exercises, and a new chapter dedicated to binary outcomes and survival analysis. It also presents numerous examples taken from the medical literature, contains exercises at the end of each chapter, and offers solutions in an appendix. The author uses Minitab and R software throughout the text for implementing the methods that are presented.

Comprehensive and accessible, Introduction to Randomized Controlled Clinical Trials is well-suited for those familiar with elementary statistical ideas and methods who want to further their knowledge of the subject.

  • Sales Rank: #2840294 in Books
  • Brand: Brand: Chapman and Hall/CRC
  • Published on: 2006-06-26
  • Released on: 2006-06-26
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.13" h x .69" w x 6.13" l, .96 pounds
  • Binding: Paperback
  • 302 pages
Features
  • Used Book in Good Condition

Review

"This remarkably well written book is both concise and thorough in covering the material that it chooses to present. Both statistical concepts and medical examples are explained in clear prose. This is the sort of book that I wish I had had when I first learned about clinical trials. . . . I particularly like Matthews' thoughtful philosophy, which carefully balances the many statistical and medical concerns in the design and analysis of clinical trials. . . . The exercises at the end of each chapter are quite helpful for testing the reader's understanding, and thorough solutions are given in the back of the book. . . . In a sea of overpriced textbooks, it is well worth the low price . . . this book will provide readers with a broad statistical foundation and hopefully whet their interest to learn m ore about clinical trials." -- JASA


About the Author
J. N. S. Matthews, University of Newcastle upon Tyne.

Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt PDF
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Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt PDF

Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt PDF

Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt PDF
Introduction to Randomized Controlled Clinical Trials, Second Edition (Chapman & Hall/CRC Texts in Statistical Science)By John N.S. Matt PDF